Engineering of staphylococcal surfaces for biotechnological applications.

Micropatterned fiber scaffolds for spatially controlled cell adhesion.

Because the local microstructure plays a pivotal role for many biological functions, a wide range of methods have been developed to design precisely engineered substrates for both fundamental biological studies and biotechnological applications. However, these techniques have been by-and-large limited to flat surfaces. Herein, we use electrohydrodynamic co-spinning to prepare biodegradable thre...

Genome-Scale Metabolic Network Models of Bacillus Species Suggest that Model Improvement is Necessary for Biotechnological Applications

Background: A genome-scale metabolic network model (GEM) is a mathematical representation of an organism’s metabolism. Today, GEMs are popular tools for computationally simulating the biotechnological processes and for predicting biochemical properties of (engineered) strains.Objectives: In the present study, we have evaluated the predictive power of two ...

undergraduated and Master students and for specialists (POSDRU project 81/3.2/S/55362) in the domains: Genetics, Microbial genetics, Molecular genetics and genetic engineering, Genetics and taxonomy of microorganisms of biotechnological importance, Molecular techniques for microorganisms with biotechnological applications, Molecular mechanisms of pathogenity

Porous polymers and resins for biotechnological and biomedical applications.

This review describes conventional and modern techniques of porous organic polymer synthesis. A huge variety of polymer architectures and functions can be gained by foaming, phase separation, imprinting or templating approaches. Several applications of porous polymers are discussed, focusing on biotechnological and biomedical applications, such as chromatography, protein synthesis, drug carrier...

Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans

UNLABELLED Staphylococcus simulans biovar staphylolyticus lysostaphin efficiently cleaves Staphylococcus aureus cell walls. The protein is in late clinical trials as a topical anti-staphylococcal agent, and can be used to prevent staphylococcal growth on artificial surfaces. Moreover, the gene has been both stably engineered into and virally delivered to mice or livestock to obtain resistance a...